Can be triggered by caloric restriction in the brain of mice.

‘Our wish is to find a way to activate CREB1, for instance through new drugs, so to keep the brain young without the need of a strict diet,’ Dr Pani said. Caloric restriction means the animals can only consume to 70 % of the food they consume normally up, and is a known experimental way to extend life, as observed in many experimental models. Typically, caloric-restricted mice do not become obese and do not develop diabetes; they show greater cognitive efficiency and memory moreover, are less aggressive.Celgene non-GAAP total revenue increases 40 percent to $1.11 Billion; GAAP Total Revenue $1.83; GAAP Diluted Earnings Per Talk about $0.54 2011 Financial Outlook Update Non-GAAP Total Revenue Expected to Increase Approximately 25 Percent Year-Over-Year to a Range of $4.45 to $4.55 Billion, Up From a Previous Selection of $4.4 to $4.5 Billion REVLIMID Net REVENUE Anticipated to Increase Approximately 26 Percent Year-Over-Year to a Range of $3.05 to $3.15 Billion, Up From a Previous Range of $3.0 to $3.1 Billion Non-GAAP Diluted Income Per Share Expected to Increase Approximately 21 Percent Year-Over-Calendar year to a Range of $3.35 to $3.40, Up From a Previous Range of $3.30 to $3.

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